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 | News: Vitamin D Reduces Risk of Multiple Sclerosis |
Numerous studies of MS have shown a correlation between disease frequency and geographic location, with the general rule being that as a person gets further away from the equator, their MS risk rises. This has often been reduced to sun exposure, with one of the more obvious implications being that sunlight causes the body to create Vitamin D--25-hydroxyvitamin D-- and therefore Vitamin D just might have a protective affect against MS.
A new study released yesterday provides compelling statistics behind that claim, saying in short that Vitamin D seems to reduce the risk of developing MS in Caucasians.. While the study does not make any claims about people who already have MS benefiting from Vitamin D supplementation...
Story continues, please click 'read more'...
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Posted by Administrator on Wednesday, December 20 @ 04:44:47 EST (4799 reads)
(Read More... | 3253 bytes more | News | Score: 3.9)
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 | Research: Vitamin D shows Promise in Treating RRMS |
A lot of attention has been made regarding the implications of Vitamin D (and in particular, its deficiency) and correlation with the development of multiple sclerosis. One large study found that low vitamin D levels were associated with MS, but did not demonstrate if taking Vitamin D AFTER diagnosis would be of any use.
This pilot study from the Mayo clinic explores that very issue. 15 relapsing-remitting MS'ers were given oral (yay!) calcitriol-- a form of Vitamin D prescribed to people who have low levels of calcium in their blood for 48 weeks. The participants were also advised to limit their dietary intake of calcium to prevent skewing the results as well as overdosing on calcium. 13 of the 15 successfully finished the trial, and were examined using expanded disability status scale, MRIs, and clinical examinations.
The results were promising. 4 patients had a total of 5 relapses in the 48 weeks, and 12 of the 13 had their EDSS stay stable within 1 point of starting. MRIs showed enhancing (active) lesions in 5 patients and baseline and 4 at the end of the study.
You know it's coming: This study showed a positive trend on a safe, easily-administered therapy, but because it is so small-- "more studies are warranted."
Click "read more" for the link to the original abstract.
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Posted by Administrator on Tuesday, August 23 @ 05:32:28 EDT (3022 reads)
(Read More... | 1650 bytes more | Research | Score: 1)
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 | Research: Supplement N-acetyl-L-cysteine (NAC) shown beneficial in EAE |
 We are huge fans of research like the following, that shows a common and readily available supplement may have beneficial therapeutic effect on MS. The supplement: N-acetyl-L-cysteine (commonly referred to as NAC), which can be obtained at most health food stores.
The study was done on the rat model of MS, EAE, which has been shown time and again to not mimic the human variant of MS. However, the pathways that NAC seems to affect are commonly accepted as being involved in human MS, so a reasonable argument could be made for applicability across the models.
Certainly, research like this is empowering and a refreshing change of pace from the "expected release in 2010" we see in pharmaceutical clinical research, but then again, the benefit of such a supplement is not quantified and has not been subject to trial in humans.
"We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats... These observations indicate that NAC treatment may be of therapeutic value in MS against the inflammatory disease process associated with the infiltration of activated mononuclear cells into the CNS."
Click "read more" for the study abstract...
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Posted by Administrator on Saturday, May 14 @ 14:30:40 EDT (2512 reads)
(Read More... | 3270 bytes more | Research | Score: 4.33)
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 | Research: An Update on Vitamin D and MS |
Earlier this year there was a lot of commotion about a study that showed Vitamin D deficiency might play a role in MS prevention. The natural question left by that study was: if Vitamin D is helpful in preventing MS from developing, is it also helpful after? This study posits that yes, Vitamin D is indeed useful to MS'ers via modulation of the immune system.
"The prevalence of MS is highest where environmental supplies of vitamin D are lowest...Administration of the active metabolite 1,25-(OH)(2)D in mice and rats with experimental allergic encephalomyelitis (EAE, an animal model of MS) not only prevented, but also reduced disease activity. ..Optimal 25OHD serum concentrations, throughout the year, may be beneficial for patients with MS, both to obtain immune-mediated suppression of disease activity, and also to decrease disease-related complications, including increased bone resorption, fractures, and muscle weakness."
Click "read more" for the full abstract...
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Posted by Administrator on Friday, August 06 @ 02:31:48 EDT (2353 reads)
(Read More... | 3065 bytes more | Research | Score: 4.5)
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 | Research: Turmeric Fights Cystic Fibrosis |
 Here's a new story about how curcumin could have a positive effect on the serious chronic illness, cystic fibrosis. Studies last year showed that turmeric could likewise have a positive effect on multiple sclerosis patients.
"A bright yellow spice common in curry might hold a key to treating deadly cystic fibrosis.
Eating large doses of a substance found in the spice turmeric significantly cut deaths among mice with the genetic disease, and scientists soon will begin studying the effects in people...
The next step: The Cystic Fibrosis Foundation is funding a first-stage study in two dozen CF patients this summer to hunt for an appropriate dose and check for side effects.
But both Caplan and the CF Foundation stress not to try curcumin treatment on your own.
Aside from possible drug interactions, treatments that help mice don't always help people — and because dietary supplements are largely unregulated, there's no proof supplies are pure, they caution."
Click "read more" to read the full story...
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Posted by Administrator on Friday, April 23 @ 00:56:41 EDT (2875 reads)
(Read More... | 7390 bytes more | Research | Score: 4.5)
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 | Research: Alpha-Lipoic Acid may be Beneficial in MS |
 Alpha-lipoic acid (ALA) is a readily available supplement... in this experiment, giving it orally to animals prevented them from getting EAE (which is supposedly the animal model of Multiple Sclerosis). However, the tricky part of this study is that in animals that had already developed EAE, it does not seem that oral administration helped, but rather an injection-administration was required :(
Still it now seems that taking ALA is a very smart thing to do for people with MS.
"alpha-Lipoic acid (alpha-LA) is a neuroprotective metabolic antioxidant that has been shown to cross the blood brain barrier. We tested whether alpha-LA is capable to prevent MOG35-55-induced experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). Daily oral administration of alpha-LA, starting at the time of immunization, significantly prevented EAE progression as compared to control mice...
Our data indicate that alpha-LA can effectively interfere with the autoimmune reaction associated with EAE through mechanisms other than its antioxidant activity and supports further studies on the use of alpha-LA as a potential therapy for MS."
Click "read more" for the full abstract...
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Posted by Administrator on Sunday, March 07 @ 05:58:01 EST (4142 reads)
(Read More... | 3234 bytes more | Research | Score: 4.8)
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 | Medicinal Herbs: Take with a grain of salt |
 A general article on using herbs to treat illness, with specific comments on Echnicea, St. John's Wort, and Ginkgo. There's also a warning about using Echnicea if you have multiple sclerosis.
"Echinacea "should not be used if you have an autoimmune disease, such as rheumatoid arthritis or multiple sclerosis," Anding said. "Like other herbs, Echinacea can also affect prescription medications and can sometimes cause allergic reactions."
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Posted by Administrator on Tuesday, February 10 @ 12:06:17 EST (2284 reads)
(Read More... | 8330 bytes more | Score: 2.33)
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