Search found 1751 matches
- Tue May 21, 2024 1:07 am
- Forum: MS Etiology and Pathogenesis
- Topic: An autoantibody signature predictive for multiple sclerosis
- Replies: 0
- Views: 271
An autoantibody signature predictive for multiple sclerosis
An autoantibody signature predictive for multiple sclerosis https://www.nature.com/articles/s41591-024-02938-3 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum...
- Tue May 21, 2024 1:00 am
- Forum: MS Etiology and Pathogenesis
- Topic: Autoantibody Profile Diagnosis
- Replies: 0
- Views: 130
Autoantibody Profile Diagnosis
Autoantibody Profile Emerged Years Before Multiple Sclerosis Diagnosis https://jamanetwork.com/journals/jama/article-abstract/2819074 About 10% of people with multiple sclerosis (MS) had an autoantibody signature that was present at least 5 years before symptoms, according to an analysis of blood s...
- Thu May 16, 2024 3:40 am
- Forum: MS Etiology and Pathogenesis
- Topic: Optical coherence tomography angiography suggests different retinal pathologies
- Replies: 0
- Views: 498
Optical coherence tomography angiography suggests different retinal pathologies
Optical coherence tomography angiography suggests different retinal pathologies https://link.springer.com/article/10.1007/s00415-024-12414-0 Abstract Background While retinal vessel changes are evident in the eyes of patients with relapsing–remitting multiple sclerosis (RRMS), changes in the vascul...
- Thu May 16, 2024 3:20 am
- Forum: MS Etiology and Pathogenesis
- Topic: Angiogenesis biomarkers discriminate multiple sclerosis phenotypes
- Replies: 0
- Views: 255
Angiogenesis biomarkers discriminate multiple sclerosis phenotypes
Angiogenesis biomarkers discriminate multiple sclerosis phenotypes https://www.researchsquare.com/article/rs-4329965/v1 Background : Multiple Sclerosis is a neuroinflammatory/neurodegenerative disease characterized by a state of “virtual hypoxia” in the central nervous system. Angiogenesis, one of ...
- Wed Mar 06, 2024 7:35 am
- Forum: General Discussion
- Topic: An interesting paper about EBV and MS
- Replies: 0
- Views: 886
An interesting paper about EBV and MS
Ineffective control of Epstein–Barr virus infection is seen in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883233/ The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world. Migration studies have shown that age at migration h...
- Wed Mar 06, 2024 7:30 am
- Forum: MS Etiology and Pathogenesis
- Topic: Plasmapheresis and Immunoadsorption: How it works
- Replies: 0
- Views: 1225
Plasmapheresis and Immunoadsorption: How it works
Miniaturized Adsorbers in Exploring the Cellular and Molecular Effects of Blood Purification https://www.mdpi.com/1422-0067/25/5/2590 Abstract Immunoadsorption (IA) has proven to be clinically effective in the treatment of steroid-refractory multiple sclerosis (MS) relapses, but its mechanism of ac...
- Tue Mar 05, 2024 12:41 pm
- Forum: MS Etiology and Pathogenesis
- Topic: Ineffective control of Epstein–Barr virus infection is seen in MS
- Replies: 1
- Views: 451
Ineffective control of Epstein–Barr virus infection is seen in MS
Ineffective control of Epstein–Barr virus infection is seen in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883233/ The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world. Migration studies have shown that age at migration h...
- Tue Mar 05, 2024 1:26 am
- Forum: MS Etiology and Pathogenesis
- Topic: 14 urine metabolites associated with PMS
- Replies: 0
- Views: 711
14 urine metabolites associated with PMS
Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids https://pubs.acs.org/doi/abs/10.1021/acschemneuro.3c00678# Abstract Multiple sclerosis (MS) is a chronic and progressive neurological disorder without a cure, but early intervention can slow disease progression and improv...
- Thu Feb 01, 2024 4:57 am
- Forum: MS Etiology and Pathogenesis
- Topic: Soluble factors in CSF
- Replies: 1
- Views: 1372
Again "soluble factors"
White matter paramagnetic rim and non-rim lesions share a periventricular gradient in multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/13524585231224681 Background : Paramagnetic rim white matter (WM) lesions (PRL) are thought to be a main driver of non-relapsing multiple sclerosis (M...
- Thu Feb 01, 2024 4:55 am
- Forum: MS Etiology and Pathogenesis
- Topic: Ibudilast reduces smouldering lesions
- Replies: 0
- Views: 974
Ibudilast reduces smouldering lesions
Slowly enlarging lesions (SEL) or "smouldering" lesions are thought to be the physiological substract of MS progression. Ibudilast reduces slowly enlarging lesions in progressive multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/13524585231224702 Background : Ibudilast has sh...
- Wed Jan 17, 2024 10:36 am
- Forum: MS Etiology and Pathogenesis
- Topic: Antivirals in MS: Tenofovir
- Replies: 4
- Views: 3195
The Answer Lies in the Details
In the Era of Antiviral Trials for MS, the Answer Lies in the Details https://www.msard-journal.com/article/S2211-0348(24)00023-3/fulltext Abstract After a seminal epidemiological study linked infection with the Epstein-Barr virus (EBV) to multiple sclerosis (MS), there is a consensus that EBV is t...
- Wed Jan 17, 2024 10:34 am
- Forum: MS Etiology and Pathogenesis
- Topic: Antivirals in MS: Tenofovir
- Replies: 4
- Views: 3195
second report
Radiologic and clinical stability in an HIV-negative MS patient after tenofovir: an updated case report https://www.sciencedirect.com/science/article/abs/pii/S2211034823008957 Introduction In 2018, members of our team published an interesting case of a patient with newly diagnosed aggressive relaps...
- Wed Jan 17, 2024 10:32 am
- Forum: MS Etiology and Pathogenesis
- Topic: Antivirals in MS: Tenofovir
- Replies: 4
- Views: 3195
Antivirals in MS: Tenofovir
Long-term MRI and clinical stability in an HIV-positive patient with multiple sclerosis on tenofovir: a case report https://www.sciencedirect.com/science/article/abs/pii/S2211034823008969 Introduction The Epstein-Barr virus (EBV) is the likely leading cause of multiple sclerosis (MS). (Bjornevik et...
- Sun Jan 14, 2024 11:51 pm
- Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
- Topic: obstruction of the glymphatic system
- Replies: 2
- Views: 1664
obstruction of the glymphatic system
The dilated veins surrounding the cord in multiple sclerosis suggest elevated pressure and obstruction of the glymphatic system https://www.sciencedirect.com/science/article/pii/S1053811924000120 Highlights • There is dilatation of the bridging veins traversing the subarachnoid space surrounding bot...
- Tue Jan 09, 2024 11:48 am
- Forum: MS Etiology and Pathogenesis
- Topic: Microglia in MS. Review
- Replies: 1
- Views: 1801