Tropospheric ozone

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O3

2017 Apr 6
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida,
Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382391/

Conclusion
Exposure to PM2.5 and O3 may in part explain geographical variation in mammographic density. Further studies are warranted to determine the causal nature of these associations.

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MS

2024 Apr 24
Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/38663930/

Conclusions: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis.

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2024 Feb 14
Department of Environmental Health, Boston University School of Public Health, Boston
Warm season ambient ozone and children's health in the USA
https://pubmed.ncbi.nlm.nih.gov/38553030/

Conclusions: Results from this national study extend prior research on the impacts of daily O3 on children's health and reinforce the presence of important adverse health impacts even at levels below the current regulatory standard in the USA.

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O3

September 2018
Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33
https://www.sciencedirect.com/science/a ... 4918300289

..Conclusion
Data demonstrate that ozone causes an immediate barrier injury that precedes myeloid cell–mediated inflammatory injury under the control of the IL-33/ST2 axis. Thus IL-33/ST2 signaling is critical for maintenance of intact epithelial barrier and inflammation.
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Neurodegenerative disorders


2024 May
ST2 levels and neurodegenerative diseases: is this a significant relation?
https://pubmed.ncbi.nlm.nih.gov/38694387/

..Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders

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O3

2024 May 1
State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, China
Ozone Chemistry on Greasy Glass Surfaces Affects the Levels of Volatile Organic Compounds in Indoor Environments
https://pubmed.ncbi.nlm.nih.gov/38691770/

Abstract

The chemistry of ozone (O3) on indoor surfaces leads to secondary pollution, aggravating the air quality in indoor environments. Here, we assess the heterogeneous chemistry of gaseous O3 with glass plates after being 1 month in two different kitchens where Chinese and Western styles of cooking were applied, respectively. The uptake coefficients of O3 on the authentic glass plates were measured in the dark and under UV light irradiation typical for indoor environments (320 nm < λ < 400 nm) at different relative humidities. The gas-phase product compounds formed upon reactions of O3 with the glass plates were evaluated in real time by a proton-transfer-reaction quadrupole-interface time-of-flight mass spectrometer. We observed typical aldehydes formed by the O3 reactions with the unsaturated fatty acid constituents of cooking oils. The formation of decanal, 6-methyl-5-hepten-2-one (6-MHO), and 4-oxopentanal (4-OPA) was also observed. The employed dynamic mass balance model shows that the estimated mixing ratios of hexanal, octanal, nonanal, decanal, undecanal, 6-MHO, and 4-OPA due to O3 chemistry with authentic grime-coated kitchen glass surfaces are higher in the kitchen where Chinese food was cooked compared to that where Western food was cooked. These results show that O3 chemistry on greasy glass surfaces leads to enhanced VOC levels in indoor environments.

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Neurodegeneration

19 Dec 2023
Association between Volatile Organic Compounds and Serum Neurofilament Light Chain in Us Adults
https://papers.ssrn.com/sol3/papers.cfm ... id=4668643

Abstract

Objective: This study aimed to investigate the associations between exposure to blood volatile organic compounds (VOCs) and the level of serum neurofilament light chain (NfL) in American adults.Methods: Data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) was utilized. We measured the levels of blood VOCs and serum NfL and used multiple linear regression models to analyze the correlation after adjusting for covariates. Stratified analyses were also conducted based on gender.Results: The study found that blood ethyl acetate and o-xylene were positively associated with elevated serum NfL levels. Gender stratified analysis revealed significant associations between male serum NfL levels and 2,5-dimethylfuran, ethyl acetate and 1,1,1-trichloroethane, while no similar significant associations were found in women.Conclusion: Exposure to blood VOCs is related to elevated serum NfL levels in US adults with potential gender-specific effects. These findings suggest that blood VOCs may play a role in revealing neurodegeneration and impacting neurological health.

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2024 May 4
School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, PR China.
Mailman School of Public Health, Columbia University, New York, NY, USA.
Deutsches Zentrum für Luft- und Raumfahrt (DLR), Institut für Datenwissenschaften, Jena, Germany.

Ozone as an environmental driver of influenza
https://pubmed.ncbi.nlm.nih.gov/38704386/


Abstract

Under long-standing threat of seasonal influenza outbreaks, it remains imperative to understand the drivers of influenza dynamics which can guide mitigation measures. While the role of absolute humidity and temperature is extensively studied, the possibility of ambient ozone (O3) as an environmental driver of influenza has received scant attention. Here, using state-level data in the USA during 2010-2015, we examined such research hypothesis. For rigorous causal inference by evidence triangulation, we applied 3 distinct methods for data analysis: Convergent Cross Mapping from state-space reconstruction theory, Peter-Clark-momentary-conditional-independence plus as graphical modeling algorithms, and regression-based Generalised Linear Model. The negative impact of ambient O3 on influenza activity at 1-week lag is consistently demonstrated by those 3 methods. With O3 commonly known as air pollutant, the novel findings here on the inhibition effect of O3 on influenza activity warrant further investigations to inform environmental management and public health protection.

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MS

2020 Apr
Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway
https://pubmed.ncbi.nlm.nih.gov/31873811/

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O3

2024 May
Insulin resistance (IR) and its relationship with long-term exposure to ozone: Data based on a national population cohort
https://pubmed.ncbi.nlm.nih.gov/38704910/

..Our study suggests long-term exposure to O3 was independently and positively associated with prevalence of IR

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MS

11 May 2023
Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross-sectional study
https://onlinelibrary.wiley.com/doi/10.1111/jne.13288

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O3

2024 May 6
Department of Epidemiology, School of Public Health, Shandong University, Jinan, China
Association between long-term exposure to ambient ozone and sperm quality in Shandong Province
https://pubmed.ncbi.nlm.nih.gov/38715497/

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MS

2018 Dec
Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark
Male factor infertility and risk of multiple sclerosis: A register-based cohort study
https://pubmed.ncbi.nlm.nih.gov/2902784 ... iliation-2

Conclusion: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.

Keywords: Male infertility; epidemiology; fertility; gender; multiple sclerosis; semen quality.

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O3


2019 Mar
Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
Tropospheric ozone and skin aging: Results from two German cohort studies

.. Thus, long-term exposure to elevated concentrations of tropospheric O3 appears to contribute to skin aging.

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Autoimmune Diseases

2024 May 3
Department of Plastic and Reconstructive Surgery, the First Hospital of Jilin University, Changchun, People's Republic of China
Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging

https://pubmed.ncbi.nlm.nih.gov/38716190/

..Conclusion: These findings indicated that autoimmune diseases play a causal role in facial skin aging. Therefore, patients with autoimmune diseases should take appropriate measures to prevent early facial aging.

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O3

Published on 23 Jun 2023
annalsofglobalhealth
The Relationship between Air Pollution and Brain Cancer: A Systematic Review and Meta-Analysis
https://annalsofglobalhealth.org/articl ... /aogh.3889

Conclusion: The results showed that exposure to air pollutants, such as O3 and PM2.5 absorbance, had the highest correlation with brain tumor incidence. They also showed an absence of correlation between exposure to certain pollutants (SO2, CO, NO2, PM10, PM2.5) and brain tumor incidence.



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MS

2015 Mar 4
Unit of Neurology, Multiple Sclerosis Center, Regina Elena National Cancer Institute, IFO , Rome , Italy
Concurrence of Multiple Sclerosis and Brain Tumors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349169/

... A recent study reported that MS patients have a decreased overall cancer risk, but an increased risk for brain tumor

2024 May 7
Impact of environmental pollutants on pediatric brain tumor incidence in New Jersey
https://pubmed.ncbi.nlm.nih.gov/38759503/

Conclusions: The results indicate a possible impact of O3 on the incidence of PBTs in NJ. In contrast to the significant links found in prior studies of adult brain tumors, the associations between PBT occurrence and particulate matter were not significant. These findings highlight the importance of further investigating how environmental factors, especially O3, relate to PBTs.

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21 September 2022
Atmosphere and Climate
Impact of meteorological conditions on tropospheric ozone and associated with parameterization methods for quantitative assessment and monitoring
https://www.frontiersin.org/articles/10 ... 81104/full

Highlights

·O3 concentrations vary with cloud reflections driven by Θz diurnal variations.

·High condensation under high humidity in the air is conducive to a re-increase in O3

·Parameterize for quantitative assessment of impact of meteorological conditions on O3

·PLOM constructs application of O3-value add theory based on multi-factor contribution

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O3 and Parkinson's Disease


2015 May
Associations of Ozone and PM2.5 Concentrations With Parkinson's Disease Among Participants in the Agricultural Health Study
https://pubmed.ncbi.nlm.nih.gov/25951420/

Results: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa.

Conclusions: The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations. Additional studies are needed to address uncertainties related to confounding and to examine temporal aspects of the associations we observed.

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O3

May–August 2022
Association between particulate matter, sulphur dioxide, nitrogen dioxide, ozone, benzo pyrene air concentrations, suicide and suicide attempts in Poland
https://www.sciencedirect.com/science/a ... 3422000173

Background and objectives

Certain air pollutants are associated with mental health conditions, like cognitive decline, depression and suicide. The aim of the study was to assess the relationship between long-term exposure to airborne concentrations of particulate matter (PM), sulphur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), benzo[a]pyrene (BaP) and suicide rates, suicide attempts and suicide attempts among people with mental disorder.
Results
Results of the study indicate that ozone is correlated with the rate of suicide attempts, the rate of total suicides and attempts at suicide attempts among people with mental disorder (r = 0.548, p < 0.001; r = 0.371, p < 0.01; r = 0.422, p < 0.01, respectively). Independent predictors of suicide attempts were high ozone concentration (β = 0.00216, p < 0.001), high feminisation and a small number of beneficiaries of environmental social welfare per 10,000 population. Completed suicide rate was associated with increased air concentrations of PM10 particulate matter (b = 0.0003, p = 0.001; β = 0.003, p < 0.001), a high number of employees and a high level of total pollutant emissions (β = 0.00027, p = 0.031)...
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Ozone pollution during the COVID-19
https://acp.copernicus.org/articles/22/4471/2022/

... The satellite and in situ observational estimates of the changes in ozone pollution associated with the pandemic lockdown show a significant enhancement of ozone in the VOC-limited regions of central and northern Europe and the Po Valley, as pointed out previously by models and in situ surface data (e.g. Menut et al., 2020; Ordóñez et al., 2020; Souri et al., 2021)

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MS


2024 May 11
Exploring suicidal ideation prevalence in multiple sclerosis patients during the COVID-19 pandemic: A study on the relationship between drug use and suicidal ideation
https://pubmed.ncbi.nlm.nih.gov/38776600/

Conclusion: The study revealed a high prevalence of suicide ideation among MS patients, emphasizing the need for tailored comprehensive support. Factors contributing to SI included limited healthcare access, fear of COVID-19 complications, social isolation, and heightened anxiety. Recommendations for healthcare providers stress early diagnosis, personalized treatment plans, and collaborative efforts to enhance the well-being of individuals with MS in Iran post-COVID-19.