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Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO

https://www.sciencedirect.com/science/a ... 8220303624

Conclusions

By inducing a super-paramagnetic susceptibility in the blood using Ferumoxytol, the vascular abnormalities in the RRMS patients were revealed and small vessel densities were obtained. This approach has the potential to monitor the venous vasculature present in MS lesions, catalogue their characteristics and compare the vascular structures spatially to the presence of lesions. These enhanced vascular features may provide new insight into the pathophysiology of MS.

frodo wrote: ↑Tue Dec 22, 2020 12:35 pm Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO

https://www.sciencedirect.com/science/a ... 8220303624

Conclusions

By inducing a super-paramagnetic susceptibility in the blood using Ferumoxytol, the vascular abnormalities in the RRMS patients were revealed and small vessel densities were obtained. This approach has the potential to monitor the venous vasculature present in MS lesions, catalogue their characteristics and compare the vascular structures spatially to the presence of lesions. These enhanced vascular features may provide new insight into the pathophysiology of MS.

Indeed! From Mark Haacke at Wayne State University in Detroit.





Fig. 6. Lesion development surrounding the perpendicular vessels as seen on the SWI-FLAIR data of two selected MS patients (A and F), along with the zoomed insets of the pre-contrast SWI-FLAIR (B and G), post-contrast SWI-FLAIR (C and H), original FLAIR (D and I) and original SWI data (E and J). These perpendicular veins abet to, what appears to be, the corona radiata (yellow traces); and were visible on both pre-contrast (blue arrows) and post-contrast data (red arrows). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Great images!! thanks.