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Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation
Posted: Sun Feb 04, 2024 1:13 pm
by DIM
Dipyridamole (DIP), a safe drug with favorable and broad pharmacological properties, inhibits EBV reactivation from B-cell lines!
https://pubmed.ncbi.nlm.nih.gov/31580916/
Re: Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation
Posted: Sun Feb 04, 2024 1:58 pm
by DIM
It has safer pharmacological profile than antivirals like Valacyclovir with less side effects, titration with an initially lower dose of dipyridamole may be considered to reduce headache side effect and thereby increase compliance.
Re: Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation
Posted: Sun Feb 04, 2024 2:11 pm
by DIM
Dipyridamole reduces microglial activity in MS model:
https://jneuroinflammation.biomedcentra ... 2094-10-89
Neuroprotective Actions of Dipyridamole on Cultured CNS Neurons:
https://www.jneurosci.org/content/jneur ... 2.full.pdf
Dipyridamole potentiate some of the vascular protective effects of endothelium-derived nitric oxide (NO), which increases cGMP by stimulating soluble guanylyl cyclase. Endothelium-derived NO is an important regulator of vascular tone, blood flow, and tissue perfusion (connection with CCSVI?)
https://www.ahajournals.org/doi/10.1161 ... 107.160226