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ThisIsMS.com :: View topic - FTY 720 for PPMS Finally!!!!
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FTY 720 for PPMS Finally!!!!

 
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Smilingface
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Joined: Apr 06, 2007
Posts: 82
Location: North Carolina

PostPosted: Tue Aug 19, 2008 8:26 pm    Post subject: FTY 720 for PPMS Finally!!!! Reply with quote

Finally, looks like it's here:

http://clinicaltrials.gov/ct2/show/NCT00731692?term=fingolimod&rank=5[url][/url]
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PPMS onset 6 years, diagnosed one and half years Vit D, Chinese Medicine Exercise.
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Frank
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Joined: Jan 04, 2007
Posts: 299
Location: Germany

PostPosted: Wed Aug 20, 2008 4:29 am    Post subject: Reply with quote

Phase-III ?
Did they ever had any former success with FTY in PPMS?

--Frank
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Current regime: Tysabri restarted 05/2008 after LDN, ABX Wheldon Regime for 1 year, interested in T-Cell vaccination, helminth immunomodulation
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Smilingface
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Joined: Apr 06, 2007
Posts: 82
Location: North Carolina

PostPosted: Wed Aug 20, 2008 4:02 pm    Post subject: FTY 720 Secondary Mechanism Reply with quote

Frank, it is the secondary mechanism of FTY 720 of stimulating nerve cells that is being tested in this arm of the current Phase III trial of FTY 720. I'm not sure how much research support there is but I first heard of the possible
second mechanism over a year ago. Let's hope Novartis is on to something!

I'm wondering how long it takes for a center to get up and running once a trial is announced. My neuro's office said today they have not gotten the final protocol yet from Novartis but they know they are a participating center.
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PPMS onset 6 years, diagnosed one and half years Vit D, Chinese Medicine Exercise.
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carolew
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Joined: Nov 06, 2004
Posts: 379
Location: Ottawa, Ont. Canada

PostPosted: Wed Aug 20, 2008 4:43 pm    Post subject: Reply with quote

Great news Smilingface!!
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CureOrBust
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Joined: Jul 28, 2005
Posts: 1330
Location: Sydney, Australia

PostPosted: Thu Aug 21, 2008 4:50 am    Post subject: Re: FTY 720 Secondary Mechanism Reply with quote

Smilingface wrote:
stimulating nerve cells that is being tested in this arm of the current Phase III trial of FTY 720. I'm not sure how much research support there is
I have read of petri dish experiments and I think of injections into mice CNS, but I am a little surprised if it was the case, we have not heard something (i.e. personal experience) from people in the current Phase III for RRMS? anyone?
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dignan
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Joined: Aug 12, 2004
Posts: 1212

PostPosted: Mon Aug 25, 2008 8:44 am    Post subject: Reply with quote

Great news Smilingface. You've been talking about this one for a while and nobody else seemed to have heard about it. If you get any more inside scoops on clinical trials, I'd love to hear about them.
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