Dietary magnesium replenishes brain magnesium. Brain magnesium is known to promote synaptogenesis.
Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake.
Nutr Neurosci. 2021 Nov 3;1-12.
Objectives: Inadequate dietary magnesium (Mg) intake is a growing public health concern. Mg is critical for diverse metabolic processes including energy production, macromolecule biosynthesis, and electrolyte homeostasis. Inadequate free Mg2+ ion concentration ([Mg2+]) in the brain is associated with several neurological and behavioral disorders. Elevating [Mg2+]in the brain using oral Mg supplementation has proven to be challenging due to the tight regulation of Mg2+ transport to the brain. This study explored the effect of short-term moderate reduction in dietary Mg intake (87% of normal Mg diet for 30 days) on [Mg2+] in the cerebrospinal fluid (CSF) ([Mg2+]CSF) and red blood cells (RBCs) ([Mg2+]RBC) in adult male rats. In addition, we investigated the effectiveness of magnesium-rich blend of Swiss chard and buckwheat extracts (SC/BW extract) in increasing brain [Mg2+] compared to various Mg salts commonly used as dietary supplements.
Methods: Animals were assigned to either normal or low Mg diet for 30 - 45 days. Following this, animals maintained on low Mg diet were supplemented with various Mg compounds. [Mg2+]CSF and [Mg2+]RBC were measured at baseline and following Mg administration. Anxiety-like behavior and cognitive function were also evaluated.
Results: The present study showed that a short-term and moderate reduction in Mg dietary intake results in a significant decline in [Mg2+]CSF and [Mg2+]RBC and the emergence of anxiety-like behavior in comparison to animals maintained on normal Mg diet. Supplementation with SC/BW extract significantly elevated [Mg2+]CSF and improved animal performance in the novel object recognition test in comparison with animals maintained on reduced Mg intake and supplemented with various Mg compounds.
Discussion: These observations indicate that brain [Mg2+] is more sensitive to a short-term and moderate reduction in Mg dietary intake than previously thought and emphasizes the importance of dietary Mg in replenishing brain Mg2+ reserves.
Free full text.
Magnesium deficient diet reduces brain magnesium and negatively impacts behavior.
Dietary magnesium raises brain (CSF) magnesium.
In contrast, all magnesium treatments raise red blood cell (RBC) levels.
Dietary magnesium benefits neurological function.
Dietary magnesium raises brain magnesium.
Re: Dietary magnesium raises brain magnesium.
that's really cool. i like seeing numbers like that - and getting some validation for a greens emphasis, too!
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
use the report button to flag problematic post content to volunteer moderators' attention.
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 1156 Views
-
Last post by Petr75
-
- 1 Replies
- 867 Views
-
Last post by NHE
-
- 0 Replies
- 1024 Views
-
Last post by NHE
-
- 0 Replies
- 1302 Views
-
Last post by NHE
-
- 2 Replies
- 2228 Views
-
Last post by NHE
-
- 0 Replies
- 1935 Views
-
Last post by frodo
-
- 6 Replies
- 3385 Views
-
Last post by NHE
-
- 0 Replies
- 1927 Views
-
Last post by NHE
-
- 0 Replies
- 12747 Views
-
Last post by accordingnature495